Parental Age, Family Size, and Risk of Multiple Sclerosis

@article{Montgomery2004ParentalAF,
  title={Parental Age, Family Size, and Risk of Multiple Sclerosis},
  author={Scott Montgomery and Mats Lambe and Tomas P. Olsson and Anders Ekbom},
  journal={Epidemiology},
  year={2004},
  volume={15},
  pages={717-723}
}
Background: Family structure, such as having siblings, provides proxy measures for a variety of characteristics relevant to disease risk. The etiology of multiple sclerosis (MS) is not well defined and analysis of family structure may provide etiologic clues. We conducted a case–control study to examine possible associations. Methods: Using the Swedish Inpatient Register, we identified 4443 patients with a diagnosis of MS. From the general Swedish population, using birth and death registers, we… Expand
No Effect of Parental Age on Risk of Multiple Sclerosis: A Population-Based Study
TLDR
Parents' age at birth is not associated with susceptibility to multiple sclerosis in a population-based Canadian cohort. Expand
Sibship characteristics and risk of multiple sclerosis: a nationwide cohort study in Denmark.
TLDR
Overall, there was no association between number of older siblings, number of younger siblings, total number of siblings, age distance from the nearest younger sibling, or exposure to younger siblings under 2 years of age and risk of MS later in life. Expand
Multiple sclerosis and risk of young-adult-onset Hodgkin lymphoma
TLDR
There may be common risks for YAHL and MS, consistent with an etiologic role in MS for early-life exposures, such as to infectious agents. Expand
Multiple sclerosis and birth order: a longitudinal cohort study
TLDR
Findings do not support the hygiene hypothesis and could be due to a cohort effect resulting from increasing MS incidence, and there is no support for the hypothesis that having older siblings protects against MS. Expand
Intrauterine environment and multiple sclerosis: a population- based case-control study
TLDR
Transplacental exposure to smoke constituents including chemicals affecting myelin may help explain any association with maternal prenatal smoking; however, it is unable to assess childhood or adult smoke exposures which may also account at least partly for this effect. Expand
Socioeconomic factors in childhood and the risk of multiple sclerosis.
TLDR
Overall, SES in childhood seems of no major importance for the subsequent risk of multiple sclerosis; however, offspring of well-educated mothers may be at a slightly reduced risk of MS. Expand
Reverse causality behind the association between reproductive history and MS
TLDR
The observed association between reproductive history and MS risk is restricted to a limited time period preceding the index year, with similar findings in both sexes, which contradicts biologic impact of pregnancy on MS risk and argues in favor of reverse causality. Expand
Shared breastfeeding & other early multiple sclerosis risk factors: A case-control study.
TLDR
The findings of this case-control study add to the accumulating evidence that early life factors could modify the risk of developing MS. Expand
Maternal diabetes and risk of multiple sclerosis in the offspring: A Danish nationwide register-based cohort study
TLDR
A nationwide cohort study utilizing high-quality register data in Denmark over several decades corroborates the view that offspring of diabetic mothers may be at an elevated risk of developing MS. Expand
Asthma onset prior to multiple sclerosis and the contribution of sibling exposure in early life
TLDR
Early life sibling exposure was associated with altered IgG serological responses to Epstein–Barr virus (EBV) and herpes simplex virus 1 (HSV1) in adulthood and appeared to contribute to the excess of asthma among MS cases by the time of MS onset. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Siblings and the Risk of Inflammatory Bowel Disease
TLDR
Having siblings is associated with the risk and phenotype of developing IBD, possibly through their influence on patterns of antigenic exposure in early life. Expand
Epidemiology of Multiple Sclerosis in US Veterans
TLDR
It is found here that latitude tier of residence at entry into active duty (EAD), years of education, and socioeconomic class were similarly associated with MS risk among white men, black men, and white women. Expand
Birth Order, Sibship Size, and Risk for Germ-Cell Testicular Cancer
TLDR
Both birth order and sibship size had an inverse and monotonically decreasing association with testicular cancer risk after adjusting for parental age, paternal socioeconomic status, and twin status. Expand
Family structure, neonatal infection, and hay fever in adolescence.
TLDR
The effects of sibship size, birth order, and infant feeding are consistent with a protective influence of postnatal infection, but the first month of life and the first postnatal exposure to allergen are not the critical periods during which this protective effect is determined. Expand
Multiple sclerosis and age at infection with common viruses.
TLDR
The hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis is supported. Expand
Advancing paternal age and the risk of schizophrenia.
TLDR
Findings support the hypothesis that schizophrenia may be associated, in part, with de novo mutations arising in paternal germ cells, and entail a need for novel approaches to the identification of genes involved in schizophrenia. Expand
Parental age and risk of sporadic and familial cancer in offspring: implications for germ cell mutagenesis.
TLDR
The results argue against major age-induced mutagenic/carcinogenic effects on germ cells as well as against age- induced adverse cancer-related hormonal effects during pregnancy, particularly in familial cancers of colon, melanoma, and thyroid. Expand
The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen.
TLDR
The principles of genome screening are described and the available results suggest that multiple sclerosis depends on independent or epistatic effects of several genes each with small individual effects, rather than a very few genes of major biological importance. Expand
Is sporadic MS caused by an infection of adolescence and early adulthood? A case‐control study of birth order position
TLDR
The results did not find an association between birth order position and the subsequent development of MS and thus do not support the concept of an infectious cause for MS where “early exposure” is protective and exposure to the infection is a single event of short duration. Expand
Multiple sclerosis and antecedent infections: A case‐control study
TLDR
The results support an association between a history of IM and subsequent MS, and an increased frequency of RTI was associated with a significantly increased risk of MS. Expand
...
1
2
3
4
5
...