Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs

@inproceedings{Fradin2010ParentOfOriginEI,
  title={Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs},
  author={Delphine Fradin and Keely Cheslack-Postava and Christine Ladd-Acosta and Craig Newschaffer and Aravinda Chakravarti and Dan E Arking and Andrew P. Feinberg and M Daniele Fallin},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Autism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been carried out to identify regions harboring genes related to autism or autism spectrum disorders, with mixed results. Given the overlap in autism features with genetic abnormalities known to be associated with imprinting, one possible reason for lack of consistency would be the influence of parent-of-origin effects that may mask the ability to… CONTINUE READING

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