• Chemistry
  • Published 2014

Parent-Metabolite Pharmacokinetic Models for Tramadol – Tests of Assumptions and Predictions

@inproceedings{Holford2014ParentMetabolitePM,
  title={Parent-Metabolite Pharmacokinetic Models for Tramadol – Tests of Assumptions and Predictions},
  author={Sam Holford and Karel Allegaert and Brian J Anderson and Butch Kukanich and Altamir Benedito de Sousa and Amir Steinman and Bruno H Pypendop and Reza Mehvar and Mario Giorgi and Nick H G Holford},
  year={2014}
}
Allometric principles were used to discern cross-species differences in (±)-tramadol disposition and formation of its primary analgesic metabolite, (±)-O-desmethyl-tramadol (M1). Species differences in formation of M1 may help predict the analgesic effectiveness of tramadol. Tramadol was administered intravenously by a zero-order (constant infusion) process or rapid bolus dose and racemic concentrations of tramadol and M1 measured. Data were pooled to define differences between species (human… CONTINUE READING

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