Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma.

@article{Metwaly2012ParenchymalstromalSF,
  title={Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma.},
  author={Hamdy Metwaly and Satoshi Maruyama and Manabu Yamazaki and Masayuki Tsuneki and Tatsuya Abe and Kai Yu Jen and Jun Cheng and Takashi Saku},
  journal={Human pathology},
  year={2012},
  volume={43 11},
  pages={
          1973-81
        }
}
It is poorly understood which cell type, tumor cells, or stromal cells are responsible for the production of extracellular matrix molecules in the neoplastic stroma. We studied the expression of 4 extracellular matrix molecules at the protein and messenger RNA levels in monocellular and 2 kinds of coculture systems between human squamous cell carcinoma (ZK-1) and fibroblast (OF-1) cell lines, which may correspond to carcinoma in situ and squamous cell carcinoma, respectively. Squamous cell… CONTINUE READING
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