Parenchymal microglia of naïve adult C57BL/6J mice express high levels of B7.1, B7.2, and MHC class II.

@article{Zhang2002ParenchymalMO,
  title={Parenchymal microglia of na{\"i}ve adult C57BL/6J mice express high levels of B7.1, B7.2, and MHC class II.},
  author={Guang Xian Zhang and Jifen Li and Elvira S. Ventura and Abdolmohamad M. Rostami},
  journal={Experimental and molecular pathology},
  year={2002},
  volume={73 1},
  pages={35-45}
}
In this study, we addressed B7.1, B7.2, and MHC class II expression on microglia of normal adult C57BL/6J mice, which are susceptible to MOG35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE). We showed that there are two distinct major populations of CD11b(+) cells in the central nervous system (CNS) of naïve mice: CD45 low (CD45(lo); parenchymal microglia) and CD45 intermediate (CD45(int); CNS-associated macrophages). These two populations compose CNS microglia. There is a… CONTINUE READING