Pardoxical cytotoxic effect of antisera used in diagnostic virology. Brief report.

  • Rainer Wigand
  • Published 1977 in
    Zentralblatt fur Bakteriologie, Parasitenkunde…


Rabbit antisera prepared against adenovirus-infected or uninfected HEK cells showed a high degree of cytotoxicity towards HeLa and other human cell cultures, while antisera prepared against infected HeLa cells did not. The toxic activity was independent of complement; it could be removed by adsorption to HEK monolayers. 


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