Pardaxin permeabilizes vesicles more efficiently by pore formation than by disruption.

  title={Pardaxin permeabilizes vesicles more efficiently by pore formation than by disruption.},
  author={Brian Stougaard Vad and Kresten Bertelsen and Charlotte Hau Johansen and Jan Mondrup Pedersen and Troels Skrydstrup and N. C. Nielsen and Daniel E Otzen},
  journal={Biophysical journal},
  volume={98 4},
Pardaxin is a 33-amino-acid neurotoxin from the Red Sea Moses sole Pardachirus marmoratus, whose mode of action shows remarkable sensitivity to lipid chain length and charge, although the effect of pH is unclear. Here we combine optical spectroscopy and dye release experiments with laser scanning confocal microscopy and natural abundance (13)C solid-state nuclear magnetic resonance to provide a more complete picture of how pardaxin interacts with lipids. The kinetics and efficiency of release… CONTINUE READING


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