Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.

@article{Burgess1995ParaxisAB,
  title={Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.},
  author={Rob Burgess and Peter Cserjesi and Keith L Ligon and Eric N Olson},
  journal={Developmental biology},
  year={1995},
  volume={168 2},
  pages={296-306}
}
During vertebrate embryogenesis, cells from the paraxial mesoderm coalesce in a rostral-to-caudal progression to form the somites. Subsequent compartmentalization of the somites yields the sclerotome, myotome, and dermatome, which give rise to the axial skeleton, axial musculature, and dermis, respectively. Recently, we cloned a novel basic helix-loop-helix (bHLH) protein, called scleraxis, which is expressed in the sclerotome, in mesenchymal precursors of bone and cartilage, and in connective… CONTINUE READING