Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes.


We present evidence showing that paraxanthine (1,7-dimethylxanthine), the main metabolite of caffeine in man, displaces the binding of [3H]SCH 23390, a radioligand which selectively labels dopamine D-1 receptors when used at low concentrations, from striatal membranes of the rat. The displacement was competitive and indicated the existence of two affinity… (More)


  • Presentations referencing similar topics