Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis.

@article{Dulloo1994ParaxanthineO,
  title={Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis.},
  author={Abdul.G. Dulloo and Josiane Seydoux and Lucien Girardier},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 1},
  pages={E801-4}
}
The notion that paraxanthine (the major dimethylated by-product of caffeine) may be a biologically active metabolite that could mediate some of the effects of caffeine was tested in relation to the well-established property of caffeine as a thermogenic stimulant. From studies measuring the in vitro respiration rates of rat brown adipose tissue in the basal state and in response to ephedrine (an enhancer of norepinephrine release from sympathetic nerve endings), it is shown that paraxanthine has… CONTINUE READING