Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels

@article{Guerreiro2008ParaxanthineTP,
  title={Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels},
  author={Serge Guerreiro and Damien Toulorge and Etienne C. Hirsch and Marc R. Marien and Pierre Sokoloff and Patrick Pierre Michel},
  journal={Molecular Pharmacology},
  year={2008},
  volume={74},
  pages={980 - 989},
  url={https://api.semanticscholar.org/CorpusID:14842240}
}
It is shown that the primary metabolite of caffeine, paraxanthine (PX; 1, 7-dimethylxanthine), was strongly protective against neurodegeneration and loss of synaptic function in a culture system of selective dopaminergic cell death, and suggested that PX has a neuroprotective potential for diseased dopamine neurons.
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52 References

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