Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle.
@article{Hawke2000ParaxanthineAC,
title={Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle.},
author={Thomas J. Hawke and David G Allen and M. Lindinger},
journal={Journal of applied physiology},
year={2000},
volume={89 6},
pages={
2312-7
},
url={https://api.semanticscholar.org/CorpusID:11369121}
}It is concluded that physiological and low pharmacological concentrations of paraxanthine result in transient, subcontracture increases in [Ca(2+)](i) in resting skeletal muscle, the magnitude of which is related to parax anthine concentration.
20 Citations
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- 2005
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- 2003
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- 2008
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25 References
Comparison of the effects of caffeine and other methylxanthines on [Ca2+]i in rat ventricular myocytes
- 1994
Medicine
It is concluded that many of the differences in the effects of these methylxanthines can be attributed to differences in membrane permeability due to Differences in oil:water partition.
Effect of caffeine on K+ efflux in frog skeletal muscle
- 1999
Biology, Chemistry
It is concluded that the caffeine-induced rise of [Ca2+]i increases K+ efflux, through the activation of two channels (BKCa and KATP) and an external Na+-dependent amiloride-sensitive process.
A mechanism for the effects of caffeine on Ca2+ release during diastole and systole in isolated rat ventricular myocytes.
- 1990
Medicine, Biology
Caffeine produced a transient increase of resting [Ca2+]i attributed to the release of Ca2+ ions from the sarcoplasmic reticulum (SR) and this increase was most obvious if the systolic contraction had previously been decreased.
The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i.
- 1990
Biology, Medicine
The shape of the caffeine contracture was found to depend on both the speed of application of caffeine and the concentration applied, and the maintained level of contraction increases over this range showing that the Ca2(+)‐independent effects of caffeine on the myofilaments have a low affinity for caffeine.
K+ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite.
- 1999
Biology, Chemistry
It is concluded that paraxanthine increases J(in)K in resting skeletal muscle by stimulating ouabain-sensitive Na+ -K+ ATPase activity in rats using a perfused rat hind limb technique.
Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse
- 1998
Biology, Medicine
The results show that the elements of the contractile machinery are differentially responsive to changes in the oxidation‐reduction balance of the muscle fibres.
Stimulation of Na+, K(+)-pump activity in skeletal muscle by methylxanthines: evidence and proposed mechanisms.
- 1996
Medicine
Evidence is presented to support the hypothesis that submillimolar concentrations of methylxanthines stimulate Na+, K(+)-ATPase activity in skeletal muscle. Administration of methylxanthines to…
Changes of myoplasmic calcium concentration during fatigue in single mouse muscle fibers
- 1991
Biology
The present results indicate that fatigue produced by repeated tetani is caused by a combination of reduced maximum tension-generating capacity, reduced myofibrillar Ca2+ sensitivity, and reducedCa2+ release from the sarcoplasmic reticulum.
Effects of caffeine on intracellular calcium concentrations in frog skeletal muscle fibres.
- 1987
Biology
The following hypothesis is proposed: low concentrations of caffeine directly induce Ca2+ release from sarcoplasmic reticulum (s.r.) in in the resting state, and facilitates Ca2- release from s.r. by depolarization and thus potentiate twitch tension.
Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.
- 1986
Chemistry, Medicine
The pharmacokinetics of caffeine (CA), paraxanthine (PX), theobromine (TB) and theophylline (TP) were studied in six healthy male volunteers after oral administration of each compound on separate…



