Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches.

  title={Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches.},
  author={Claude Robert and Laurence Bourgeais and Charles-Daniel Arreto and Miguel Cond{\'e}s-Lara and Rodrigo Noseda and Th{\'e}r{\`e}se Jay and Luis H Villanueva},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 20},
While functional imaging and deep brain stimulation studies point to a pivotal role of the hypothalamus in the pathophysiology of migraine and trigeminal autonomic cephalalgias, the circuitry and the mechanisms underlying the modulation of medullary trigeminovascular (Sp5C) neurons have not been fully identified. We investigated the existence of a direct anatomo-functional relationship between hypothalamic excitability disturbances and modifications of the activities of Sp5C neurons in the rat… CONTINUE READING
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