Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect.

@article{Darambazar2015ParaventricularNI,
  title={Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect.},
  author={Gantulga Darambazar and Masanori Nakata and Takashi Okada and Lei Wang and EnXu Li and Atsumi Shinozaki and Megumi Motoshima and Masatomo Mori and Toshihiko Yada},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={456 4},
  pages={913-8}
}
An adipokine leptin plays a central role in the regulation of feeding and energy homeostasis via acting on the hypothalamus. However, its downstream neuronal mechanism is not thoroughly understood. The neurons expressing nucleobindin-2 (NUCB2)-derived nesfatin-1 in the hypothalamic paraventricular nucleus (PVN) have been implicated in feeding and energy homeostasis. The present study aimed to explore the role of PVN NUCB2/nesfatin-1 in the leptin action, by using adeno-associated virus (AAV… CONTINUE READING
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