Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes.

@article{Dliot2005ParathyroidHT,
  title={Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes.},
  author={Nadine D{\'e}liot and Nati Hernando and Zeya Horst-Liu and Serge Mike Gisler and Paola Capuano and Carsten A Wagner and Desa Bacic and Stephen O'brien and Juerg Biber and Heini Murer},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 1},
  pages={C159-67}
}
The type IIa Na+-P(i) cotransporter (NaP(i)-IIa) and the Na+/H+ exchanger regulatory factor-1 (NHERF1) colocalize in the apical membrane of proximal tubular cells. Both proteins interact in vitro. Herein the interaction between NaP(i)-IIa and NHERF1 is further documented on the basis of coimmunoprecipitation and co-pull-down assays. NaP(i)-IIa is endocytosed and degraded in lysosomes upon parathyroid hormone (PTH) treatment. To investigate the effect of PTH on the NaP(i)-IIa-NHERF1 association… CONTINUE READING

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