Parathyroid hormone suppresses osteoblast apoptosis by augmenting DNA repair.

@article{Schnoke2009ParathyroidHS,
  title={Parathyroid hormone suppresses osteoblast apoptosis by augmenting DNA repair.},
  author={Matthew Schnoke and Sharon B Midura and Ronald J. Midura},
  journal={Bone},
  year={2009},
  volume={45 3},
  pages={590-602}
}
Daily injection of parathyroid hormone (PTH) is a clinically approved treatment for osteoporosis. It suppresses apoptosis of bone-forming osteoblasts although its exact anti-apoptotic mechanism(s) is incompletely understood. In this study, PTH treatment of cultured osteoblasts blocked the pro-apoptotic effects of serum withdrawal and nutrient deprivation… CONTINUE READING