Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells.

@article{Dossing2001ParathyroidHS,
  title={Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells.},
  author={Debra A Dossing and Julie M Radeff and Jacob Sanders and Sun Kyeong Lee and Mingli Hsieh and Paula H. Stern},
  journal={Bone},
  year={2001},
  volume={29 3},
  pages={223-30}
}
Studies with antagonists have provided evidence that protein kinase C (PKC) is involved in several of the actions of parathyroid hormone (PTH) on bone. PTH increases total PKC activity in bone and bone cells. The current studies investigated whether PTH can activate specific PKC isozymes, as demonstrated by translocation of these isozymes from cytosolic to membrane fractions. The isozymes selected for study, alpha, betaI, delta, epsilon, and zeta, were shown previously by us to be present in… CONTINUE READING