Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas.

@article{Cantley1985ParathyroidHS,
  title={Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas.},
  author={Larry K. Cantley and David A. Ontjes and Cary W. Cooper and Colin G. Thomas and George S. Leight and Samuel A. Wells},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1985},
  volume={60 5},
  pages={1032-7}
}
The in vitro secretion of PTH by dispersed human parathyroid cells was examined under conditions of low and high extracellular Ca+2 using tissue from patients with primary hyperparathyroidism and hyperparathyroidism resulting from chronic renal failure (CRF). The PTH secretion rate (nanograms of PTH per 10(5) cells/h) was lower in adenomatous tissues than in either primary hyperplastic cells or CRF cells under conditions of low (0.5 mM) or high (2.0-3.0 mM) extracellular Ca+2. Among the… CONTINUE READING
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