Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth.

@article{GarciaOcaa1995ParathyroidHP,
  title={Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth.},
  author={Adolfo Garcia-Oca{\~n}a and Fernando de Miguel and Cristina Penaranda and Juan P. Albar and Jos{\'e} Luis Sarasa and Pedro Esbrit},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1995},
  volume={10 12},
  pages={1875-84}
}
Parathyroid hormone-related protein (PTHrP), a likely mediator for humoral hypercalcemia of malignancy, is also synthesized in various normal tissues. In the kidney, PTHrP, mainly detected in proximal and distal tubules, has been shown to stimulate proliferation of rat mesangial cells in culture. Experiments were carried out to investigate the possible mitogenic effect of PTHrP in cultures of rabbit proximal tubule cells (PTC). Immunocytochemical analysis, using antihuman (h)PTHrP antibodies to… CONTINUE READING