Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells.

@article{Stuart2000ParathyroidHP,
  title={Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells.},
  author={William D. Stuart and Shigeto Maeda and Paramjit K. Khera and James A. Fagin and Thomas L. Clemens},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={279 1},
  pages={
          E60-7
        }
}
In this study, we investigated the mechanisms responsible for the growth-inhibitory action of parathyroid hormone-related protein (PTHRP) in A10 vascular smooth muscle cells (VSMC). Fluorescence-activated cell sorting analysis of serum-stimulated VSMC treated with PTHRP or dibutyryl-cAMP (DBcAMP) demonstrated an enrichment of cells in G1 and a reduction in the S phase. Measurement of DNA synthesis in platelet-derived growth factor-stimulated VSMC treated with DBcAMP revealed that cells became… Expand
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