Parathyroid hormone-related protein in prostate cancer.

  title={Parathyroid hormone-related protein in prostate cancer.},
  author={Farrokh Asadi and Subhash C. Kukreja},
  journal={Critical reviews in eukaryotic gene expression},
  volume={15 1},
Although originally discovered as the peptide responsible for humoral hypercalcemia of malignancy (HHM), parathyroid hormone-related protein (PTHrP) has been shown to play a major role in fetal development. In the adult, it is widely distributed in normal and various cancer tissues. In spite of the rarity of HHM in prostate cancer, PTHrP is widely distributed in prostate cancer cells. PTHrP is a precursor molecule with generation of various fragments with distinct biological activities. More… CONTINUE READING

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