Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains

@article{PortalNez2018ParathyroidHP,
  title={Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains},
  author={S. Portal-N{\'u}{\~n}ez and J. Ardura and D. Lozano and I. Mart{\'i}nez de Toda and M. de la Fuente and G. Herrero-Beaumont and R. Largo and P. Esbrit},
  journal={Bone & Joint Research},
  year={2018},
  volume={7},
  pages={58 - 68}
}
  • S. Portal-Núñez, J. Ardura, +5 authors P. Esbrit
  • Published 2018
  • Chemistry, Medicine
  • Bone & Joint Research
  • Objectives Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTH-related protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal… CONTINUE READING
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