Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma.

@article{Monego2010ParathyroidHP,
  title={Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma.},
  author={Giovanni Monego and Libero Lauriola and Sara Ramella and Rolando Maria D'Angelillo and Paola Lanza and Pierluigi Granone and Franco Oreste Ranelletti},
  journal={Chest},
  year={2010},
  volume={137 4},
  pages={898-908}
}
BACKGROUND In many primary tumors, parathyroid hormone-related peptide (PTHrP) and PTHrP type 1 receptor (PTH1R) are coexpressed, supporting the possibility that PTHrP/PTH1R system can mediate important signals for tumor progression through paracrine/autocrine mechanisms. In non-small cell lung carcinoma the clinical relevance of the expression of PTH1R remains to be investigated. METHODS Fifty-four lung adenocarcinomas of mixed histologic type from patients with stage I and II cancer were… CONTINUE READING