Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

@article{Benawadh2014ParathyroidHR,
  title={Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.},
  author={Abdullah Nasser Ben-awadh and Jes{\'u}s Delgado-Calle and Xiaolin Tu and Kali Kuhlenschmidt and Matthew R Allen and Lilian Irene Plotkin and Teresita M. Bellido},
  journal={Endocrinology},
  year={2014},
  volume={155 8},
  pages={
          2797-809
        }
}
PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH receptor signaling only in osteocytes in transgenic mice (DMP1-caPTHR1) was sufficient to increase Rankl expression and bone resorption. Resorption in DMP1-caPTHR1 mice crossed… CONTINUE READING
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