Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation.

@article{Pettway2008ParathyroidHM,
  title={Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation.},
  author={Glenda J. Pettway and Jeffrey A. Meganck and Amy Koh and Evan Keller and Steven A. N. Goldstein and L. McCauley},
  journal={Bone},
  year={2008},
  volume={42 4},
  pages={806-18}
}
PTH (1-34) is the only FDA-approved anabolic agent for osteoporosis treatment in the U.S., but its mechanisms are not completely understood. This study investigated PTH effects on osteogenic cells at various stages of differentiation and proliferation using an engineered bone growth model in vivo. Ossicles were generated from bone marrow stromal cells (BMSCs) implanted in immunocompromised mice. Three weeks of PTH (40 microg/kg/day) or vehicle treatment initiated 1 day, 1, 2, or 3 weeks after… CONTINUE READING
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