Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.

@article{Pfister1998ParathyroidHL,
  title={Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.},
  author={Markus F. Pfister and Irina Ruf and Gerti Stange and Urs Ziegler and Eleanor DeLand Lederer and Juerg Biber and Heini Murer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 4},
  pages={1909-14}
}
We have studied the involvement of proteolytic pathways in the regulation of the Na/Pi cotransporter type II by parathyroid hormone (PTH) in opossum kidney cells. Inhibition of lysosomal degradation (by leupeptin, ammonium chloride, methylamine, chloroquine, L-methionine methyl ester) prevented the PTH-mediated degradation of the transporter, whereas inhibition of the proteasomal pathway (by lactacystin) did not. Moreover it was found (i) that whereas lysosomal inhibitors prevented the PTH… CONTINUE READING
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