Parathyroid hormone-induced translocation of Na-H antiporters in rat proximal tubules.

@article{Hensley1989ParathyroidHT,
  title={Parathyroid hormone-induced translocation of Na-H antiporters in rat proximal tubules.},
  author={C B Hensley and Michael E. Bradley and Austin K. Mircheff},
  journal={The American journal of physiology},
  year={1989},
  volume={257 4 Pt 1},
  pages={C637-45}
}
Parathyroid hormone (PTH) is believed to inhibit bicarbonate reabsorption by inhibiting Na-H antiport activity in proximal tubular brush-border membranes. The sequence of events triggered by PTH was investigated in a crude preparation of proximal tubules obtained by mechanical disruption and filtration through nylon mesh filters. Tubule samples were subjected to analytical subcellular fractionation after 2-, 5-, and 30-min treatments with 1 IU/ml PTH. These PTH-treatment intervals caused 54, 63… CONTINUE READING

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