Parathyroid hormone gene variant and calcific aortic stenosis.

  title={Parathyroid hormone gene variant and calcific aortic stenosis.},
  author={Fabian Schmitz and Silke Ewering and Klaus Zerres and Sebastian Klomfass and Rainer Hoffmann and Jan Rudolf Ortlepp},
  journal={The Journal of heart valve disease},
  volume={18 3},
BACKGROUND AND AIM OF THE STUDY Calcific aortic stenosis (AS) is the most frequently acquired valvular disease of the elderly in the Western world. A genetic background for AS has been proposed. The deposition of calcium hydroxyapatite is the key problem of valve calcification; vitamin D and parathyroid hormone are major factors in calcium homeostasis. The vitamin D receptor (VDR) gene and parathyroid hormone (PTH) gene variants were selected as candidate genes. METHODS A total of 538… CONTINUE READING