Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis.

@article{Usatii2007ParathyroidHF,
  title={Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis.},
  author={Mariana Usatii and Louise Rousseau and Christian Demers and J-L Petit and J. H. Brossard and Marielle Gascon-Barr{\'e} and Jeffrey R. Lavigne and Richard J. Zahradnik and Edward F. Nemeth and P. D'amour},
  journal={Kidney international},
  year={2007},
  volume={72 11},
  pages={
          1330-5
        }
}
Carboxyl (C)-terminal fragments of parathyroid hormone (PTH) oppose the calcemic, phosphaturic, and bone-resorbing effects of active hormone. To study the action of these fragments on 1,25(OH)(2)D (1,25-dihydroxyvitamin D) synthesis, we infused parathyroidectomized rats with human or rat active 1-34 or 1-84 PTH at doses selected to produce similar calcemic responses. Human active PTH influenced neither phosphate nor 1,25(OH)(2)D concentrations. However, active 1-34 rat PTH decreased phosphate… CONTINUE READING
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