Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells.

@article{AbouSamra1989ParathyroidHC,
  title={Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells.},
  author={Abdul. B. Abou-Samra and Harald W Jueppner and D P Westerberg and JohnT. Potts and Gino V. Segre},
  journal={Endocrinology},
  year={1989},
  volume={124 3},
  pages={
          1107-13
        }
}
PTH binds to specific receptors that are coupled to adenylate cyclase and activate cAMP-dependent protein kinase. Since it has been shown that PTH activates phospholipid inositol metabolism, we investigated whether PTH influences protein kinase-C (PKC) activity in rat osteosarcoma (ROS) cells 17/2.8 that contain a large number of PTH receptor. Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Similar Papers

Loading similar papers…