Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.

@article{Gensure2005ParathyroidHA,
  title={Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.},
  author={Robert C. Gensure and Thomas J. Gardella and Harald W Jueppner},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={328 3},
  pages={666-78}
}
Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor). The different biological effects of these ligands result from their modes of regulation and secretion, endocrine vs. paracrine/autocrine. The importance of PTH and PTHrP is evident by the variety of clinical… CONTINUE READING