Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells.

@article{Reid1987ParathyroidHA,
  title={Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells.},
  author={Ian R Reid and Roberto Civitelli and Linda R. Halstead and Louis V. Avioli and Keith A. Hruska},
  journal={The American journal of physiology},
  year={1987},
  volume={253 1 Pt 1},
  pages={E45-51}
}
Changes in cytoplasmic calcium concentration ([Ca2+]i) activate numerous cellular processes thus mediating the effects of a number of hormones, but whether this mechanism is involved in the activation of osteoblasts by parathyroid hormone (PTH) remains uncertain. To examine this question, [Ca2+]i has been measured in suspensions of UMR 106 cells, a rodent osteosarcoma cell line with an osteoblastic phenotype. Basal [Ca2+]i was 137 +/- 3.7 nM (n = 60) and after the addition of rat PTH-(1-34… CONTINUE READING

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