Parathyroid hormone (PTH)/PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells.

@article{Guo1995ParathyroidH,
  title={Parathyroid hormone (PTH)/PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells.},
  author={Jishun Guo and A Iida-Klein and Xiao-jian Huang and Abdul Badi Abou-Samra and Gino V. Segre and F. Richard Bringhurst},
  journal={Endocrinology},
  year={1995},
  volume={136 9},
  pages={3884-91}
}
We showed previously that a single species of cloned PTH/PTH-related peptide (PTHrP) receptors, when stably expressed in LLC-PK1 kidney cells, couples to multiple second messenger signals and biological responses. To address the linkages of individual messenger signals to specific biological responses in these cells, we examined the relations among PTH/PTHrP receptor expression, PTH-activated phospholipase C (PLC) and adenylyl cyclase, and PTH-regulated phosphate transport in LLC-PK1 cells that… CONTINUE READING

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