Parathyroid hormone/parathyroid hormone-related peptide type 1 receptor in human bone.

@article{Langub2001ParathyroidHH,
  title={Parathyroid hormone/parathyroid hormone-related peptide type 1 receptor in human bone.},
  author={M. Chris Langub and Marie-Claude Monier-Faugere and Qing-hui Qi and Zhaopo Geng and Nicholas J. Koszewski and Hartmut H. Malluche},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 3},
  pages={448-56}
}
The parathyroid hormone/parathyroid hormone-related peptide (PTH/PTHrP) receptor (denoted as PTH-1R) is a key signaling factor through which calcium-regulating hormones PTH and PTHrP exert their effects on bone. There are contradictory reports regarding the capability of osteoclasts to express PTH-1R. To address this issue in humans, bone biopsy specimen samples from 9 normal controls and 16 patients with moderate to severe secondary renal hyperparathyroid bone disease (2 degrees HPT) with… CONTINUE READING

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