Parathyroid Xenotransplantation without Immunosuppression in Experimental Hypoparathyroidism: Long-term In Vivo Function following Microencapsulation with a Clinically Suitable Alginate

@article{Hasse2000ParathyroidXW,
  title={Parathyroid Xenotransplantation without Immunosuppression in Experimental Hypoparathyroidism: Long-term In Vivo Function following Microencapsulation with a Clinically Suitable Alginate},
  author={Christian Hasse and Thomas Bohrer and Peter Barth and Benno Stinner and Richard Cohen and Hubert Cramer and U. Zimmermann and Matthias Rothmund},
  journal={World Journal of Surgery},
  year={2000},
  volume={24},
  pages={1361-1366}
}
Permanent hypoparthyroidism is one of the most difficult of all endocrine disorders to treat medically. Because this deficiency syndrome rarely is a life-threatening condition, systemic immunosuppression for recipients of transgenic transplants is not justified. An alternative would be protecting the tissue to be transplanted from the immunologic response (immunoisolation) by coating it with a semipermeable membrane- microencapsulation. Unfortunately, prior to the first clinical use, further… CONTINUE READING

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