Parathyroid Hormone-Related Protein

  title={Parathyroid Hormone-Related Protein},
  author={Robert A. Nissenson},
  journal={Reviews in Endocrine and Metabolic Disorders},
Interest in the etiology of malignancy-associated hypercalcemia (MAH) led to the discovery of a novel factor capable of reproducing many of the actions of parathyroid hormone (PTH) on bone and mineral metabolism. This factor was shown to circulate in suf®cient levels to be responsible for hypercalcemia, hypophosphatemia, and increased bone resorption in the majority of MAH patients with solid tumors. The early ®nding that PTH-related protein (PTHrP) is capable of binding with high af®nity to… CONTINUE READING


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