Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy

@article{Mozar2016ParathyroidHP,
  title={Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy},
  author={A. Mozar and H. Lin and K. Williams and C. Chin and Rosemary Li and N. G. Kondegowda and A. F. Stewart and A. Garc{\'i}a-Oca{\~n}a and R. Vasavada},
  journal={PLoS ONE},
  year={2016},
  volume={11}
}
  • A. Mozar, H. Lin, +6 authors R. Vasavada
  • Published 2016
  • Biology, Medicine
  • PLoS ONE
  • Aims/Hypothesis Finding ways to stimulate the regeneration of endogenous pancreatic beta cells is an important goal in the treatment of diabetes. Parathyroid hormone-related protein (PTHrP), the full-length (1–139) and amino-terminal (1–36) peptides, enhance beta cell function, proliferation, and survival. Therefore, we hypothesize that PTHrP(1–36) has the potential to regenerate endogenous beta cells. Methods The partial pancreatectomy (PPx) mouse model of beta cell injury was used to test… CONTINUE READING
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    References

    SHOWING 1-10 OF 54 REFERENCES
    Systemic and acute administration of parathyroid hormone-related peptide(1–36) stimulates endogenous beta cell proliferation while preserving function in adult mice
    • 20
    • PDF
    Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.
    • 171
    • Highly Influential
    • PDF
    PTHrP increases pancreatic β-cell-specific functions in well-differentiated cells
    • 18