Parathyroid Hormone Modulates the Response of Osteoblast-Like Cells to Mechanical Stimulation

@article{Ryder2000ParathyroidHM,
  title={Parathyroid Hormone Modulates the Response of Osteoblast-Like Cells to Mechanical Stimulation},
  author={Kimberly D Ryder and Randall L. Duncan},
  journal={Calcified Tissue International},
  year={2000},
  volume={67},
  pages={241-246}
}
Mechanical loading stimulates many responses in bone and osteoblasts associated with osteogenesis. Since loading and parathyroid hormone (PTH) activate similar signaling pathways in osteoblasts, we postulate that PTH can potentiate the effects of mechanical stimulation. Using an in vitro four-point bending device, we found that expression of COX-2, the inducible isoform of cyclooxygenase, was dependent on fluid forces generated across the culture plate, but not physiologic levels of strain in… CONTINUE READING