Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

@inproceedings{Brown2018ParathyroidH,
  title={Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer},
  author={Hannah K. Brown and Gloria Allocca and Penelope D. Ottewell and Ning Wang and Nicola J Brown and Peter Ian Croucher and Colby L. Eaton and Ingunn Holen},
  booktitle={International journal of molecular sciences},
  year={2018}
}
Breast cancer cells colonize the skeleton by homing to specific niches, but the involvement of osteoblasts in tumour cell seeding, colonization, and progression is unknown. We used an in vivo model to determine how increasing the number of cells of the osteoblast lineage with parathyroid hormone (PTH) modified subsequent skeletal colonization by breast cancer cells. BALB/c nude mice were injected for five consecutive days with PBS (control) or PTH and then injected with DiD-labelled breast… CONTINUE READING
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