Parasympathetic regulation of heart rate in rats after 5/6 nephrectomy is impaired despite functionally intact cardiac vagal innervation.

Abstract

BACKGROUND Chronic renal failure is frequently associated with a high risk of sudden cardiac death due to dysfunction of the autonomic nervous system. The pathogenic mechanisms underlying the parasympathetic cardiac dysautonomia are not fully elucidated yet. METHODS Chronic renal failure was induced in rats by 5/6 nephrectomy. Blood pressure, resting… (More)
DOI: 10.1093/ndt/gfp123

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