Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.

@article{Katayama2007Parasporin1AN,
  title={Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.},
  author={Hideki Katayama and Yoshitomo Kusaka and Haruo Yokota and Tetsuyuki Akao and Masayasu Kojima and Osamu Nakamura and Eisuke Mekada and Eiich Mizuki},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 10},
  pages={7742-52}
}
Parasporin-1 is a novel non-insecticidal inclusion protein from Bacillus thuringiensis that is cytotoxic to specific mammalian cells. In this study, we investigated the effects of parasporin-1 on toxin-sensitive cell lines to elucidate the cytotoxic mechanism of parasporin-1. Parasporin-1 is not a membrane pore-forming toxin as evidenced by measurements of lactate dehydrogenase release, propidium iodide penetration, and membrane potential in parasporin-1-treated cells. Parasporin-1 decreased… CONTINUE READING

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