Parasite-specific lactate dehydrogenase for the diagnosis of Plasmodium falciparum infection in an endemic area in west Uganda.

@article{Jelinek1996ParasitespecificLD,
  title={Parasite-specific lactate dehydrogenase for the diagnosis of Plasmodium falciparum infection in an endemic area in west Uganda.},
  author={Tomas Jelinek and Albert H D Kilian and Martin Henk and E B Mughusu and Hans Dieter Nothdurft and Thomas L{\"o}scher and Juergen Knobloch and F Van Sonnenburg},
  journal={Tropical medicine & international health : TM & IH},
  year={1996},
  volume={1 2},
  pages={227-30}
}
The measurement of parasite lactate dehydrogenase (pLDH) has been presented as an easy and rapid method for the diagnosis of malaria in humans. In order to evaluate the sensitivity and specificity of such a test we examined blood samples from 429 Ugandan patients. While pLDH activity was significantly linked to parasitaemia, sensitivity and specificity were found to be rather low at 58.8 and 62.2% respectively. The positive and negative predictive values failed to meet necessary standards. We… CONTINUE READING