Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

@article{Nutman1987ParasitespecificAI,
  title={Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.},
  author={Thomas B Nutman and Vasanthapuram Kumaraswami and Eric A. Ottesen},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={79 5},
  pages={1516-23}
}
The antigen-specific immune unresponsiveness seen in bancroftian filariasis was studied by examining lymphokine production in peripheral blood mononuclear cells (PBMC) or PBMC subpopulations from 10 patients with asymptomatic microfilaremia, 13 patients with elephantiasis and 6 normal North Americans. In each group of patients, the kinetics of the lymphokine response and the response to mitogens and nonparasite antigens did not differ significantly. In marked contrast, when antigen-induced… CONTINUE READING

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