Parasite selection for immunogenetic optimality.

@article{Wegner2003ParasiteSF,
  title={Parasite selection for immunogenetic optimality.},
  author={K Mathias Wegner and Martin Kalbe and Joachim Kurtz and T. B. H. Reusch and Manfred Milinski},
  journal={Science},
  year={2003},
  volume={301 5638},
  pages={1343}
}
In vertebrates, genes of the major histocompatibility complex (MHC), with their pronounced polymorphism, potentially represent outstanding examples for the selective advantages of genetic diversity (1). Theoretical models predicted that, within an individual, MHC alleles can be subjected to two opposing selective forces, resulting in an optimal number of genes at intermediate individual MHC diversity (2, 3). Diversifying selection increases heterozygosity and enables wider recognition of… CONTINUE READING
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Supporting Online Material www.sciencemag.org/cgi/content/full

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Materials and Methods are available as supporting online material on Science Online

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To whom correspondence should be addressed. Email: wegner@mpil-ploen.mpg

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