Parasite load estimation by qPCR differentiates between asymptomatic and symptomatic infection in Indian visceral leishmaniasis.

@article{Sudarshan2014ParasiteLE,
  title={Parasite load estimation by qPCR differentiates between asymptomatic and symptomatic infection in Indian visceral leishmaniasis.},
  author={Medhavi Sudarshan and Shyam Sundar},
  journal={Diagnostic microbiology and infectious disease},
  year={2014},
  volume={80 1},
  pages={
          40-2
        }
}
Using quantitative PCR (qPCR), we differentiated asymptomatic and symptomatic Indian Leishmania donovani infection. qPCR on blood of 40 visceral leishmaniasis, 130 endemic, and 40 non-endemic healthy controls showed 500 times less (P < .0001) parasitemia in asymptomatic compared to the symptomatic ones and threshold of 5 parasite genome/mL for the clinical disease. 
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