Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.

@article{Mou2013ParasitederivedAI,
  title={Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.},
  author={Zhirong Mou and Helen M. Muleme and Dong Liu and Ping Jia and Ifeoma Benedette. Okwor and Shiby M. Kuriakose and Stephen M Beverley and Jude Eze Uzonna},
  journal={Journal of immunology},
  year={2013},
  volume={190 7},
  pages={
          3380-9
        }
}
The breakdown of L-arginine to ornithine and urea by host arginase supports Leishmania proliferation in macrophages. Studies using arginase-null mutants show that Leishmania-derived arginase plays an important role in disease pathogenesis. We investigated the role of parasite-derived arginase in secondary (memory) anti-Leishmania immunity in the resistant C57BL/6 mice. We found that C57BL/6 mice infected with arginase-deficient (arg(-)) L. major failed to completely resolve their lesion and… CONTINUE READING

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