Parasite Load Induces Progressive Spleen Architecture Breakage and Impairs Cytokine mRNA Expression in Leishmania infantum-Naturally Infected Dogs

@inproceedings{Cavalcanti2015ParasiteLI,
  title={Parasite Load Induces Progressive Spleen Architecture Breakage and Impairs Cytokine mRNA Expression in Leishmania infantum-Naturally Infected Dogs},
  author={Amanda dos Santos Cavalcanti and Marcelo Ribeiro-Alves and Luiza de Oliveira Ramos Pereira and Gustavo Leandro da Cruz Mestre and Anna Beatriz Robottom Ferreira and Fernanda Nazar{\'e} Morgado and Mariana C{\^o}rtes Boit{\'e} and Elisa Cupolillo and Milton Oz{\'o}rio Moraes and Renato Porrozzi},
  booktitle={PloS one},
  year={2015}
}
Canine Visceral Leishmaniasis (CVL) shares many aspects with the human disease and dogs are considered the main urban reservoir of L. infantum in zoonotic VL. Infected dogs develop progressive disease with a large clinical spectrum. A complex balance between the parasite and the genetic/immunological background of the host are decisive for infection evolution and clinical outcome. This study comprised 92 Leishmania infected mongrel dogs of various ages from Mato Grosso, Brazil. Spleen samples… CONTINUE READING
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