Parasite Burden and CD36-Mediated Sequestration Are Determinants of Acute Lung Injury in an Experimental Malaria Model

@article{Lovegrove2008ParasiteBA,
  title={Parasite Burden and CD36-Mediated Sequestration Are Determinants of Acute Lung Injury in an Experimental Malaria Model},
  author={Fiona E. Lovegrove and Sina A Gharib and Lourdes Pex00F1a-Castillo and Samir N. Patel and John T. Ruzinski and Timothy R. Hughes and W Conrad Liles and Kevin C Kain},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={1326 - 1334}
}
Although acute lung injury (ALI) is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria (CM); however, no model of malaria-induced lung injury has been definitively established. This study used bronchoalveolar lavage (BAL), histopathology and gene expression analysis to examine the development of ALI in mice… CONTINUE READING