Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction

@article{Tomita2002ParaquatinducedGE,
  title={Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction},
  author={Masafumi Tomita and Tsutomu Nohno and Toshiko Okuyama and Shin-ichiro Nishimatsu and Junko Adachi},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={530-537}
}
Increased formation of reactive oxygen species is a cause of paraquat (PQ)-induced injury and also provides a link between the signaling pathways and transcriptional events that regulate the expression of a large number of genes. However, the molecular mechanisms involved in PQ-induced injury remain unclear. To investigate the changes in gene expression at the onset of PQ injury, we used the differential display-polymerase chain reaction (PCR) method. Rats were treated intraperitoneally with 20… CONTINUE READING