Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts.

@article{Tung2010ParaquatIC,
  title={Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts.},
  author={J Tung and Y. D. Lang and Leng-fang Wang and C Chen},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 3},
  pages={803-8}
}
Survivors of paraquat poisoning are left with pulmonary fibrosis which results in a restrictive type of long-term pulmonary dysfunction. Connective tissue growth factor (CTGF) is a key growth factor that initiates tissue repair and underlies the development of lung fibrosis. Angiotensin (ANG) II may induce CTGF expression in the heart and kidney and plays… CONTINUE READING